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A few maintain around 25% of the weight long-term, but the majority regain the rest

Adding Once-Daily Lixisenatide for Type 2 Diabetes Inadequately Controlled by Established Basal Insulin: A 24-Week, Randomized, Placebo-Controlled Comparison (GetGoal-L)

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For those taking concurrent diabetes medications, dose adjustments may be necessarythe Ozempic SmPC and BNF advise considering reduction of sulfonylurea or insulin doses when initiating GLP-1 receptor agonists to minimise hypoglycaemia risk