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13 As the first orally administered GLP-1 RA, oral semaglutide provides an option for patients unwilling or unable to self-inject
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The fusion product is resistant to DPP-4 degradation, due to an alanine to glycine substitution at position 2 (A2G) in each of the peptide sequences 28,29 , and has a plasma half-life of five days on average in humans 30,31,32
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F., Calanna, S., Davies, M., Dicker, D., Garvey, W
