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Colonic biopsies from these patients also show reduced GLP-1R expression, suggesting that decreased GLP-1 and GLP-1R expression may underlie the efficacy of ROSE-010 in alleviating IBS-C abdominal pain [61]

In another study, the effects of ascending doses of RG7697 administered subcutaneously to 38 non-diabetic subjects over 96 h were evaluated [125]

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