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Animal studies have shown potential risks with GLP-1 drugs during pregnancy, and these medications should be discontinued before conception if possible

Core concepts in pharmacoepidemiology: Confounding by indication and the role of active comparators

Overall, the multimorbidity of depression and T2DM involves shared genetic risk factors and multiple underlying biological mechanisms, including HPA axis dysregulation, pro-inflammatory states, gut-brain axis interactions, and insulin signaling alterations, which can affect neurotransmission