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To see the best response to a GLP-1 medication, patients should generally follow the six pillars of Lifestyle Medicine, Glickman says

In clinical trials, retatrutide has shown weight loss exceeding 24% of body weight, surpassing both semaglutide and tirzepatide

Patients with high-responder genetic profiles might successfully maintain weight on lower, more affordable doses, while others benefit from dual-compound approaches like GLP-Squared

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Using your FSA to cover both medication and genetic optimization testing extends your healthcare dollars further while personalizing your weight loss approach