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Methods We searched PubMed and Cochrane up to 11 November 2023 for RCTs with an intervention duration of at least 12 weeks assessing s.c

SRS-positive patients showed lower expression levels of insulin, proinsulin, and GLP- 1R than SRS-negative patients

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Subgroup analysis for treatment durations6 months indicated a higher WL in the GLP-1RAs group (SMD=0.79, 95% CI 0.25 to 1.34)