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Biomedicine & Pharmacotherapy

Unlike traditional medications such as disulfiram, naltrexone, and buprenorphine, which primarily target neurotransmitter pathways directly associated with addiction, GLP-1RAs modulate reward mechanisms indirectly through metabolic and neuroendocrine pathways

Sermorelin Sermorelin is the original growth hormone releasing hormone analog, and it remains relevant for menopausal weight management despite being overshadowed by newer compounds

J Am Board Fam Med 26:203210 Meier JJ (2012) GLP-1 receptor agonists for individualized treatment of type 2 diabetes mellitus

They have both gone through extensive clinical programmes, including cardiovascular outcomes trials, and have shown beneficial effects [22, 26, 27]