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In another phase II study, a fixed combination of a long-acting analogue of the islet peptide amylin (cagrilintide) with semaglutide at 2.4 mg (cagrisema) produced weight losses of 15.5% and 2.18% reductions in HbA 1c in obese individuals with T2DM [44]

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Patients treated with oral semaglutide experienced clinically significant weight loss, as well as a reduction in body mass index and waist circumference [35,36,37,38,39,40]

Effects of glucagon-like peptide-1 analog liraglutide on the systemic inflammation in high-fat-diet-induced mice

The greatest neuroprotective effects were seen by the use of DA4-JC and DA-CH5 which improve motor function, protect dopaminergic neurons, reduce inflammation, and rescue glial cell line-derived neurotrophic factor levels [114]