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Winfrey said she combined medications with hiking, running, resistance training, and consuming a healthy diet. Even in clinical trials, like those for Zepbound, participants combine medication with lifestyle interventions like diet and exercise

While no direct drug interaction exists between semaglutide and ibuprofen, both medications independently affect the gastrointestinal system, requiring informed caution

If your urine is consistently light yellow to clear, you are probably adequately hydrated

6) Consider OTC options with clinician guidance Lifestyle steps are first-line for many people

If you experience nausea, eating smaller, more frequent meals and staying hydrated can help stabilize your stomach