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Since retatrutide is not yet available, tirzepatide is the next best option among approved medications, as it produces greater liver fat reductions than semaglutide

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FDA has raised specific concerns about compounded GLP-1 products: Reports of adverse events (including hospitalizations) tied to dosing errors with compounded injectable semaglutide Concerns about the use of semaglutide salt forms (sodium/acetate) rather than the base form used in FDA-approved products FDA has stated it is not aware of a lawful basis for compounding using these different salt forms Broader concerns about compounded GLP-1 dosing and titration beyond labeled dosing protocols Important distinction : Compounded medications prepared by state-licensed pharmacies operating under federal and state compounding frameworks are different from illegally marketed or counterfeit products sold online without valid prescriptions