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Injection Technique and Timing Subcutaneous injection sites include the abdomen (avoiding the two-inch area around the navel), front and outer thigh, and back of the upper arm

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Seek urgent medical attention (contact 111 or attend A&E) if you experience: Severe or persistent diarrhoea lasting more than 48 hours, particularly if accompanied by fever, blood in stools, or severe abdominal pain Signs of dehydration : extreme thirst, dizziness or lightheadedness, significantly reduced urine output, dark-coloured urine, confusion, or rapid heartbeat Severe abdominal pain that is different from your usual IBS symptoms, especially if constant or worsening Persistent vomiting preventing you from keeping down fluids or medications Signs of pancreatitis : severe upper abdominal pain radiating to the back, nausea, and vomiting (a rare but serious side effect of GLP-1 agonists) Allergic reactions : rash, itching, swelling, severe dizziness, or difficulty breathing Contact your GP or prescribing clinician within 1-2 days if you experience: Moderate diarrhoea affecting your daily activities or quality of life Persistent nausea or reduced appetite preventing adequate nutrition Worsening of IBS symptoms despite taking linaclotide Inadequate weight loss response to Wegovy after 3-6 months New or worsening abdominal symptoms that concern you Difficulty tolerating either medication due to side effects Questions about medication timing, dosing, or interactions with other medicines Routine follow-up appointments should be maintained as scheduled by your healthcare provider, typically every 3-6 months once treatment is established

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Pediatric obesity-assessment, treatment, and prevention: an Endocrine Society clinical practice guideline

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