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This suggests that GLP1-RAs may be particularly useful in obesity-related mood disorders

This uncertainty may reflect limitations in statistical power, particularly for MR-Egger, which requires stronger assumptions and larger sample sizes to detect causal effects

For gastrointestinal symptoms commonly associated with GLP-1 therapy, research on specific strains (though not in GLP-1 users specifically) includes: Lactobacillus rhamnosus GG (ATCC 53103) has evidence for diarrhoea management Bifidobacterium lactis BB-12 and Bifidobacterium longum BB536 have been studied for constipation relief Lactobacillus plantarum 299v has some evidence for bloating and abdominal discomfort Colony-forming units (CFUs) indicate the number of viable bacteria per dose

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