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GLP-1 agonists: Uses, benefits, and risks

doi: 10.1001/jamanetworkopen.2024.27258, 57

Glucagon-like peptide-1 (GLP-1) is a hormone produced by the small intestine, which is responsible for triggering the pancreas to release insulin, blocking the secretion of another hormone called glucagon, slowing digestion, and making you feel full after eating

Consistent with these findings, peripherally administered CCK induces cFos immunoreactivity in GLP-1-producing neurons of the hindbrain vagal complex of the NTS [354], and surgical vagal deafferentation reduces CCK-induced NTS neuronal cFos activation by approximately 50% [355]

These medications are administered either as subcutaneous injections (daily or weekly, depending on the formulation) or, in the case of semaglutide (Rybelsus), as an oral tablet
