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Description
GLP-1R regulates brain glucose metabolism The most prominent physiological effect of GLP-1 and GLP-1R is the regulation of insulin secretion in the pancreas to maintain postprandial glucose homeostasis, whereas outside the pancreas, GLP-1 and GLP-1R also regulate feeding and metabolism through the nervous system
Add-On to Basal Insulin or Basal Insulin + MET) Efficacy of study medications on body weight in SUSTAIN-5 was presented in Table 34

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While clinical evidence 52,53 has indicated a possible elevated risk, causality has not been established
