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Familial PD genes (Parkin [ PRKN , also known as PARK2 ] and PINK1 ) implicate impaired mitophagy in disease progression (63), fluorodeoxyglucose PET (FDG-PET) studies show consistent cerebral glucose hypometabolism (64), and hypothalamic dysfunction has been linked to ALS and HD (65)

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This timeline requires patience, but the collective process typically produces better outcomes than individual litigation

Overall, the combination of GLP-1 agonists and metformin can be a powerful therapeutic strategy for achieving weight loss and improving metabolic health in individuals with type 2 diabetes or obesity

This creates a natural pathway for weight managementwithout relying solely on medications