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As they are thinly or un-myelinated, autonomic nerves may be especially susceptible to vascular and metabolic insult

Shortages may occur
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GLP-1RA can enhance renal function and renal blood flow, facilitate the recovery of vascular endothelial function, reduce urinary protein, and play a protective role in the kidney

Furthermore, clinicians must exercise a low threshold for cessation should weight loss occur rapidly ( 1% of body weight/week) or signs of liver decompensation develop
