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Intracerebroventricular application of GLP-1R agonist binds to GLP-1R on both neurons and astrocytes in the NTS

5 A 2024 study suggests that semaglutide (GLP-1 RA) drugs may lower your cravings for sweet foods by improving taste sensitivity, changing the gene expression on your tongue thats responsible for taste perception, and even changing the way your brain responds to sweet tastes

However, the exaggerated effect of GLP-1 on postprandial insulin secretion in surgical subjects is not significantly different in those with and without recurrent hypoglycaemia. This means that additional factors are probably involved in the hypoglycaemic response seen in some GB patients

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