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Description
161,167 Small molecule GLP-1RAs Currently, most GLP-1RAs are based on proteins or peptides, meaning they are large molecules typically administered via injection

This mechanism significantly reduces the risk of hypoglycemia when used alone, though this risk increases when combined with insulin or sulfonylureas
In the protein sector, U.S
18 However, its rapid hydrolysis by intestinal lactase and SGLT1 inhibition causing diarrhea limited its clinical use
Its recent investment programme which includes facility expansions aligned with Annex 1 guidance reinforces a forward-thinking approach
