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11 An elevated level of leptin causes the secretion of proinflammatory factors like TNF alpha and interleukin 6

Moloney AM, Griffin RJ, Timmons S, OConnor R, Ravid R, ONeill C

Weight management becomes significantly harder for people living with thyroid disease, as metabolism directly depends on thyroid hormone levels

They can do so without needing to go through any FDA approval process
