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M., Brunelle C

In our study, we noticed a significant reduction of LDL-C, TC, VLDL-C, and TG among participants with GLP-1RAs that were in consistency with Aoki et al

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However, given the large and growing body of preclinical literature highlighting mechanisms outside of body weight contributing to sex differences in effects of GLP-1R agonism (eg, interactions with estrogen), the case for meaningful and potentially clinically relevant differences remains, if not strong, then at least certainly warranting careful attention to sex as an important variable in GLP-1 system research