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PPAR- is also highly expressed in adipose tissue where it controls adipocyte differentiation and plays a crucial role in increasing insulin sensitivity and promoting fatty acid uptake into adipocytes.[88], [89] The phase IIb trial of elafibranor, GOLDEN-505, was an international, randomised, placebo-controlled trial of 276 patients with biopsy proven NASH in the absence of cirrhosis, with a primary outcome of resolution of NASH defined by disappearance of steatosis, ballooning or lobular inflammation