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In females only, GE2 reduced visceral (gonadal) fat, reduced inflammation in the dorsal hippocampus and improved basal blood glucose in response to a WD

can be used as a preventive treatment prior to starting GLP-1 agonists

This is a worthy read to give a comprehensive presentation as to the risks/benefits as well as the need for vigilance.

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When appetite is reduced, it may be helpful to include protein at meals and snacks
