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This interval allows: GI side effects (nausea, vomiting, diarrhea) from the current dose level to subside The body to adapt to the rate of gastric emptying at that dose Clinicians to assess tolerability before increasing further Time to reach maximum dose At the four-week escalation schedule used in Phase 2 trials, participants reached the 12mg maximum dose at week 20 (after five four-week steps: 1mg, 2mg, 4mg, 8mg, 12mg)

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The JPML initially appointed Judge Gene E

I'm really hoping this will make a noticeable difference in how I approach my meals and snacks throughout the day