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However, the incidence rates of first-time prescribing and dispensing of the three GLP-1 receptor agonists (liraglutide, semaglutide, and tirzepatide) overall was low across the observed period for the patient population eligible for GLP-1 treatment for cardiovascular disease and overweight or obesity

Beyond that, multiple studies demonstrate an association between the amount of weight loss and taste changes outlined above and even conclude that taste changes post-surgically may be exacerbated by weight loss suggesting a causal relationship between weight and taste perception [83,84]

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On the aversion side, GLP-1 receptors sit presynaptically on medial habenula terminals in the interpeduncular nucleus, where agonism potentiates glutamatergic input and brings forward nicotine's aversive properties