glp-1 drugs alzheimer's Novo Nordisk's oral drug didn't work on as hoped, but don't call it a failure What's Next for Alzheimer's Treatment?

Lebrun LJ, Lenaerts K, Kiers D, Pais de Barros JP, Le Guern N, Plesnik J, et al

Interestingly, the tested GLP-1 agonists outperformed the traditional AUD medications in reducing AUD-related hospitalization risks, highlighting their potential as a novel treatment approach

However, the small study population, open-label design and the lack of blindness are significant limitations that need to be considered when interpreting the data

Both alcohol use and alcohol related deaths increased in the US during the COVID-19 pandemic 5,6

Volcano plot visualization of GLP-1MK-801 relative to vehicle revealed transcripts associated with glutamatergic signalling, such as Grin2a , Grin2b , Shisa6 and Slc17a7 among the most differentially upregulated genes (Fig