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The 5 types of lipedema were first described by Scmeller and Meier Vollrath, and the criteria by Meier-Volarath in 2007, as described below

The primary endpoint was the percentage change in body weight from baseline to 24 weeks

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Pathogenic processes lead to ALS neurodegeneration, including mitochondrial dysfunction, apoptosis, chronic inflammatory reactions mediated by cytokine production, free radical generation, decreased neurogenesis, synaptic loss, synaptic death, excitotoxicity, axonal transport impairment, and neurotrophic factor dysregulation [137]

However, this outlook might be overly optimistic