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After years of surgical and medical weight loss care, I can say this clearly: Tirzepatide is one of the most powerful non-surgical tools we have ever had for obesity and metabolic disease

GLP-1RAs are considered safe and reduce the risk of severe hypoglycemia in patients with chronic kidney disease

But if the prevention trials confirm what the observational data suggests, this class of drugs could change dementia care more than anything we've seen in decades

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Here are five GLP-1 programs worth knowing about in 2026, ranked with the strongest overall option first