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Over the past few years, there has been an increasing discussion about the potential cardiovascular benefits of sodium-glucose cotransporter 2 inhibitors (SGLT2Is) and glucagon-like peptide-1 receptor agonists (GLP-1RAs)

But now you understand the full picture: Metformin the trusted first step GLP-1 agonists weight loss + blood sugar control SGLT2 inhibitors protect your heart and kidneys DPP-4, Sulfonylureas, TZDs supporting medicines for different needs Tirzepatide the powerful new option of 2025 Insulin not a last resort, but a natural and effective treatment Remember no medication works alone

*Correspondence: Baptist Gallwitz [email protected] This article was submitted to Molecular and Structural Endocrinology, a section of the journal Frontiers in Endocrinology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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70 GLP-1RAs confer substantial benefits for individuals with AS owing to their multifaceted impact on various aspects of cardiovascular health