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GLP-1 receptor agonists, including semaglutide, are increasingly used to treat obesityand to a lesser extent, type 2 diabetesin children and adolescents

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In addition, this report is a consensus of expert endocrinologists representing South Asian countries including India, Pakistan, Bangladesh, Nepal, Sri Lanka, Afghanistan and the Maldives on essential recommendations related to the use of GLP-1 RAs in a real-world scenario.

GLP-1RAs provide cardioprotective benefits through glycaemic and non-glycaemic effects, including improved insulin secretion and action, body-weight loss, blood-pressure lowering and improved lipid profile, as well as via direct effects on the heart and vasculature

GLP-1 in the periphery (outside the CNS) has been shown to act on the brain to reduce food ingestion