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While Tirzepatide targets GLP-1 and GIP receptors, Retatrutide goes further by also acting on glucagon receptors, which contributes to its enhanced weight loss effects demonstrated in trials

Both the 120 mg dose group ( P = .002) and the 150 mg dose group ( P = .001) had greater weight loss than placebo

GLP-1 receptor agonists (semaglutide in Wegovy/Ozempic) and dual GIP/GLP-1 agonists (tirzepatide in Zepbound/Mounjaro) mimic gut hormones that act on appetite-regulating regions of the brain, slow stomach emptying, and increase satiety

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