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187 The incretin hormones play a crucial role in maintaining metabolic homeostasis via augmentation of insulin secretion from islet-beta-cells: the incretin effect accounts for 6070% of total insulin released from the pancreas during the postprandial period

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1 Researchers acknowledged the genetic effect on weight loss was relatively small but said the findings lay the foundation for precision medicine approaches to obesity treatment by providing direct evidence that variation in drug-target genes contributes to differences in how patients respond