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Smaller Biotechs and Collaborators: Companies like Zealand Pharma, Glycadia, and others have GLP-1 analogs or co-agonists in early trials, often in partnership with larger pharma (e.g., Novo Nordisk collaboration with Zealand)

Vzquez-Manrique RP, Farina F, Cambon K, et al

GLP-1 is notably produced by hindbrain PPG neurons, mainly in the nucleus tractus solitarius (NTS) and the medullary intermediate reticular nucleus (IRT) 4

As we achieve greater weight loss with any GLP-1 medicine, greater adverse events are common

Common physical changes patients describe after GLP-1-supported weight loss include: Looser skin around the abdomen, flanks, and lower back Sagging or bat wing tissue along the upper arms Thigh skin that appears crepey or hangs when sitting or standing Decreased fullness in the breasts or buttocks Less volume in the face, particularly the cheeks and under the eyes These changes can feel surprising