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Other Serious Risks Intestinal Blockage (Ileus) Added to Label: September 2023 Symptoms: Severe abdominal pain, inability to pass gas or stool, severe bloating, vomiting Risk: Can require emergency surgery to correct Pancreatitis Added to Label: January 2025 Symptoms: Severe upper abdominal pain, nausea, vomiting, fever Risk: Necrotizing pancreatitis can be life-threatening Kidney Injuries Added to Label: January 2025 Cause: Often related to severe dehydration from persistent vomiting Risk: Acute kidney injury requiring hospitalization Gallbladder Disease Research: 2023 JAMA study linked higher doses to increased risk Symptoms: Severe pain in upper right abdomen, nausea, jaundice Outcome: Often requires gallbladder removal surgery The Side Effects Everyone Gets (But Still Takes the Drug) Nausea: ~50% of users (RAND survey) Diarrhea: ~33% of users Stopped Due to Side Effects: 13% of users Stopped Due to Cost: 14% of users According to the RAND American Life Panel survey of 8,793 Americans, about half of GLP-1 users experienced nausea and roughly one-third experienced diarrhea

The medical director of the VCU Health Medical Weight Loss Program explains what these medications do to the body and why they might not be suited for everyone

Key Takeaways GLP-1 medication costs with insurance: what to expect Understanding and managing side effects of GLP-1 medications How GLP-1 medications help with joint pain and inflammation Overcoming insurance denials: strategies and support GLP-1 medications for PCOS and weight loss GLP-1 Medication Costs with Insurance: What to Expect The cost of GLP-1 medication with insurance can vary widely based on your plan, pharmacy, and use of prescription coupons

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Previous research indicates that lifestyle counselling, exercise interventions, antipsychotic substitution, discontinuation and dose reduction may represent potential avenues for treatment, although their efficacy is limited [11,12,13,14,15]