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Catanese, L

Abbreviations AC, Adenylyl Cyclase

The proposed pathway is consistent with the Kamel-Abusalha hypersomnolence signal, the absence of a parasomnia or RLS signal, and the directionally similar (though much weaker) parkinsonism trend orexin signaling has documented interactions with dopamine and motor systems

Abbreviations DPP-4: Dipeptidyl-peptidase 4 EXAMINE: Examination of Cardiovascular Outcomes with Alogliptin versus Standard of Care GLP-1: Glucagon-like peptide 1 PYO: Patient-year of exposure SAVOR-TIMI 53: The Saxagliptin Assessment of Vascular Outcomes Recorded in Patients with Diabetes Mellitus (SAVOR)Thrombolysis in Myocardial Infarction (TIMI) 53 trial References Butler PC, Elashoff M, Elashoff R, Gale EA (2013) A critical analysis of the clinical use of incretin-based therapies: are the GLP-1 therapies safe

Originally developed for type 2 diabetes, these medications have emerged as powerful tools in the battle against excess weight