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Endocrinology 139 , 30643071 (1998)

For tirzepatide, the recommended washout period is at least 1 month before planned conception

Clinical research on Wegovy has demonstrated that people can lose about 20% of their body weight over a 68-week period, with additional studies supporting the medications sustained results over time

Fatty acid accumulation causes insulin resistance through insulin signaling cascades, which counteracts increased glucose uptake and glycolysis 46
