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Because non-hormonal IUDs dont rely on hormones to prevent pregnancy, theres no possibility for semaglutide to interfere with hormone balance when using a copper IUD

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10.1001/jama.2015.9676 16 DaviesM

Caution is also warranted when dismissing smaller quantitative sex differences in the therapeutic or adverse effect outcomes, especially considering the staggeringly large numbers of patients taking GLP-1-based therapeutics

Moreover, a real-world-study-based CEA is an analytic framework for health economic evaluation that complements evidence from trial- or model-based CEAs because it is more generalizable