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2 This effect may arise from mechanisms involving reduced ectopic fat accumulation and better cellular glucose uptake

Serious but Rare Side Effects Less common but more serious side effects can include: Pancreatitis Severe abdominal pain that requires immediate medical attention Gallbladder problems May cause pain in the upper right abdomen Severe gastroparesis Stomach paralysis that can be dangerous Kidney problems Changes in urination or swelling Severe allergic reactions Reported in less than 1% of patients Diabetic retinopathy In people with diabetes Possible risk of thyroid cancer Only seen in animal studies and not in humans Low blood sugar Particularly if taken with other diabetes medications like insulin These serious side effects occur in less than 1% of patients but require immediate medical evaluation if symptoms develop

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Our healthcare providers work collaboratively with patients to create a comprehensive plan that includes GLP-1 medications, dietary changes, increased physical activity, and behavioral support

The PREFER study was an open-label, multicenter, randomized, crossover study assessing patient preference for dulaglutide and semaglutide injection devices [130]