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Furthermore, in vivo experiments utilizing rotenone-induced mouse model of PD revealed a significant rise in plasma GLP-1 after CGA administration (50 mg/kg, orally for 13 weeks) with concomitant increase in colonic GPR-40 and GPR-43 mRNA expression
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The problem with Ozempic isn't that it fails
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However, some patients do report irritability, which is most often related to indirect factors such as under-eating, blood sugar fluctuations, sleep disruption, or changes in reward signaling rather than the medication itself.This post explains the science behind these effects, identifies who may be more vulnerable, and outlines practical strategies clinicians and patients can use to reduce risk
