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2020 doi: 10.1021/acs.jmedchem.0c00740
Interestingly, the residues at multiple positions (12, 16, 17, 20, 21, 24 and 28) of the multi-targeting agonists are highly solvent-accessible and of limited contact with GLP-1R, allowing them to employ distinct amino acids from GLP-1 without altering GLP-1R signaling profiles
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Derosa G, Maffioli P, Salvadeo SA, Ferrari I, Ragonesi PD, Querci F, et al
