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Most programs require physician documentation of medical necessity, baseline weight and BMI, and proof of unsuccessful prior treatments
Patients with a history of pancreatitis, gallbladder disease, or severe gastroparesis may require careful consideration of risks versus benefits

This section addresses those considerations with the important caveat that retatrutide combination protocols have not been studied in clinical trials, and combining investigational compounds introduces compounding unknowns

These measures help patients develop confidence, improve administration accuracy, and may reduce early discontinuation

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