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The semaglutide group showed a significantly improved Kansas City Cardiomyopathy Questionnaire clinical summary score and a longer 6-min walking distance from baseline (21.5 m and 1.2 m in the semaglutide and placebo groups, respectively, intergroup difference 20.3 m, 95% CI 8.632.1 m), compared with that in the placebo group despite the relatively short observation period of 52 weeks

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Although proposed mechanismssuch as modulation of the HPA axis and central GLP1 receptor signallingsuggest potential antidepressant effects, clinical findings remain inconsistent

McPheeters M, OConnor EA, Riley S, Kennedy SM, Voisin C, Kuznacic K, et al

Europe: The European Medicines Agency oversees the approval of incretin mimetics, with drugs like Exenatide and Semaglutide approved since 2008