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The intake does not use a validated PHQ-2 or PHQ-9 depression instrument (mental health is covered by the suicidal/homicidal and eating disorder gates), does not split personal vs family history into separate questions on MTC or MEN-2 (theyre combined in a single you or a family member prompt), and does not include a dedicated opioid or broader substance-use screen beyond alcohol dependence

Kidney function, liver enzymes, and electrolytes should be checked at baseline and every 36 months

All PlexusDx formulations are HSA/FSA eligible, accessible in all 50 states, and require no insurance or membership fees

Additional descriptive findings regarding the impact of living with a smoker among non-smokers are presented in Supplementary Table S2

For any compound to work transdermally, it must be small enough to penetrate through multiple skin layers and achieve therapeutic concentrations in the bloodstream