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And in the STEP trials, patient-reported physical functioning improved more on the drug than on placebo (STEP patient-reported outcomes, 2024), because unloading forty pounds of fat does more for how a body moves than a modest dip in muscle takes away

doi: 10.1007/s13668-025-00649-w

When these small steps are consistent, GLP-1 medications become far more effective

For instance, unimolecular doses of the dual-receptor agonist tirzepatide has effects that closely resemble dulaglutide, a pure GLP-1RA