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This means dose increases do not produce immediate full effects

84 In contrast, MPTP treatment reduces TH-positive neurons, decreases concentrations of dopamine as well as its metabolites 3,4-dihydroxyphenylacetic acid and homovanillic acid, and increases the ratio of dopamine metabolites to dopamine

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10.1016/j.physbeh.2011.02.028 55 GunawardanaS
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