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[DOI] [PubMed] [Google Scholar] 16.Madsen O

Because of semaglutide, we lost fat and muscle, and then we might lose bone too. Parker said if a patient is extremely overweight, the muscle loss associated with semaglutide is worth it to reach a healthy weight

Another study showed that acute administration of exenatide was associated with increased hepatic glucose uptake during an oral glucose tolerance test (OGTT) and a reduction in endogenous glucose production, reinforcing the hypothesis of a direct action of GLP-1 on the liver [12]

They may also offer greater convenience and may be easier to scale and distribute than injectable alternatives

Preclinical evidence supporting GIPR antagonism emerged from studies using mice with a global, germline GIPR knockout (KO) [22,23]