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To what extent there exists functional or even anatomical connectivity between the peripheral and central GLP1 systems was comprehensively addressed in a very recent series of experiments in mice (Brierley et al., 2021)

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The journey from discovery of the GLP-1 hormone to treatments for diabetes and then obesity was a long and stuttering one, spanning more than four decades and involving hundreds of researchers across academia and the pharmaceutical industry

Carpenter, B., Nehm, R., Warne, T., Leslie, A

Its typically most pronounced at the beginning of treatment and sometimes when dosage is increased