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However, in PD pathogenesis, oligomerisation of S downregulates Sirt3 (Park et al., 2020), resulting in decreased phosphorylation of AMPK and increased phosphorylation of Drp1, impairing mitochondrial respiration, and leading to apoptosis

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Glucagon-like peptide 1 protects pancreatic beta-cells from death by increasing autophagic flux and restoring lysosomal function