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This observation has raised concerns regarding suboptimal drug exposure, altered pharmacokinetics, and heightened inflammatory burden in obese patients, highlighting the potential need for dose optimization or alternative treatment strategies in this population (63, 64)
Mounjaro activates both GLP-1 and GIP receptors, while Ozempic only targets GLP-1
The FDA has issued warnings about thyroid cancer risk based on animal studies that connected these drugs to medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN 2)
