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The absence from this map worth noting is Roche, whose publicly disclosed obesity strategy is concentrated on dual GLP-1/GIP (CT-388) and does not include a triple-agonist deal or disclosed internal program

others discontinue due to nausea or side effects

GLP-1 reduces appetite and improves insulin release
This type of structured escalation yields far richer data than a single fixed-dose trial would have allowed

Additionally, due to operational considerations and variability in the insured population over time, there is currently no interest in conducting these analyses over long time horizons
