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Clinical evidence shows that stopping GLP-1 therapy usually leads to weight regain and worsening blood sugar control

Satiety and Nausea: Both activate satiety centers in the hypothalamus, which may contribute to the nausea commonly seen during drug initiation or dose escalation

Since commercial patients tend to be younger and healthier than Medicare beneficiaries, early GLP-1 use is reinforcing its role as a reliable foundation for diabetes care and could be a contributing factor to rising rates of monotherapy

Acta Endocrinologica (Copenhagen) 1963;44:139149

Another recent report suggests that incretin-stimulation of insulin secretion requires incorporation of glutamate in the insulin granules